The man was riding in the 300 block of South 29th Street on Thursday around 4:30 p.m.
A preliminary investigation by police shows that the man veered into traffic and collided with a vehicle.
Upon arrival officers observed the man was being treated by Emergency Medical Services.
The man was transported to a local hospital where they died as a result of his injuries.
The Harrisburg Police Traffic Safety Unit responded, and is conducting the investigation.
Anyone with additional information is asked to call the Harrisburg Police, at 717-558-6900.
Click here to follow Daily Voice York and receive free news updates.